IHO056

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Synopsis

By experimentally manipulating sleep, we will explore the impact and aspects (e.g., staging, fragmentation, arousal) of sleep quantity/quality on next-day pain and test the relevance of our pre-clinical findings in humans with LBP by verifying: (1) potential mechanisms that explain how sleep influences pain, and (2) factors that facilitate or impede (e.g., exercise) this interaction. We will also assess the validity of four common consumer wearables (e.g., Whoop) for measuring sleep quantity, continuity and basic architecture in this population in the “real-world” by comparing the data to that acquired by a PSG setup. This research will take advantage of existing equipment and online platforms/infrastructure, a database of LBP participants, and ongoing funding support (e.g., US NIH). AIM 1: Test the hypothesis that poor sleep worsens next-day LBP via specific neuroimmune pathways, and that these changes are attributed to specific indices of sleep such as slow wave sleep. AIM 2: Evaluate the accuracy of multiple latest generation consumer wearables for quantifying indices of sleep quantity, continuity and basic architecture in people with LBP in the real-world.